Fedratinib: Introduction, Prescription, Intake, Side Effects, Doses, Precautions, and Interactions

What is Fedratinib?

Fedratinib is prescribed to cure myelofibrosis in adults.

Myelofibrosis is a type of bone marrow cancer that is very uncommon.  This condition affects your body’s ability to generate blood cells.

It may also be utilized for purposes not mentioned in this concise clinical guide.

What are the common conditions in which Fedratinib prescribed?

This drug is generally administered to the people struggling with myelofibrosis, a sort of bone marrow cancer.

How should I take Fedratinib?

Adhere closely to the instructions of your doctor or as mentioned on the prescription label of the medicine. Your doctor may sometimes alter your dose. Take the medicine precisely as suggested.

The medicine can be used along with food or without it. However, if Fedratinib troubles your stomach, then prefer high- fat meals.

Before and after administering you with this medicine your vitamin B1 (thiamine) levels will be tested. If needed, you may be asked to take vitamin B1 supplement.

Other antiemetic medicines to help control nausea, vomiting and diarrhoea may be recommended. Take these medicines for prescribed periods of time.

Some people who take Fedratinib got vitamin B1 deficiency which may at times lead to severe and fatal brain damage.

Despite taking preventive medicines if diarrhoea or vomiting persists immediately visit your doctor. Due to continuous vomiting and diarrhoea, you are likely get undernourished which can result in low vitamin B1 levels.

Fedratinib can decline your blood cell counts and impact functioning of liver. You may often undergo blood tests. These results may even defer the timing of your cancer treatments.

Do not tamper your dose or discontinue Fedratinib except with instructions of your medic.

Store at room temperature in a cool and dry place.

Typical Adult Dose for Myelofibrosis:

For patients with a baseline platelet count of 50 × 109/L or more:
400 mg doses are taken orally once in a day

When you should not take Fedratinib?

Inform your doctor if you faced:

  • low platelets or red blood cells count;
  • Hepatic illnesses
  • kidney disease; or
  • if you have been using ruxolitinib (Jakafi).

It is yet undiscovered if this medicine will affect an unborn infant. Apprise your doctor if you are pregnant or plan to become pregnant.

Do not take the medicine while breastfeeding, withdrawal symptoms may arise in the nursing baby.

If you experience signs such as drowsiness, confusion, memory issues, vision problems, queer eye movements, or coordination and muscle movement problems.

Visit your medic if you suffer from diarrhoea and vomiting while taking antiemetic medications.

What are the possible side effects of Fedratinib?

If you experience any symptoms of allergic reaction such as hives; shallow breathing; swelling of your face, lips, tongue, or throat, hasten for emergency medical help.

Some people who take Fedratinib got vitamin B1 deficiency which may at times lead to severe and fatal brain damage.

Seek immediate medical attention if you experience symptoms such as:

  • Sleepiness, misperception, memory glitches;
  • Vision difficulties, queer eye movements; or
  • Coordination problems and issues in muscle movement.

Meet your doctor without delay if you get:

  • Severe or constant nausea, vomiting, or diarrhoea (even while taking antiemetic)
  • Easy bruising, abnormal bleeding, purple or red spots beneath the skin;
  • Less red blood cells (anaemia): pale skin, unusual fatigue, shortness of breath, cold feet and hands, dizziness; or
  • How white blood cell: fever, mouth sores, skin sores, sore throat, cough, trouble breathing.

You may get a blood transference if you have intensely low blood count.

Common side effects may comprise:

  • Nausea, Vomiting;
  • Diarrhoea; or
  • Anaemia.

However, these all are not the only possible side- effects, as it may show in other symptoms as well. Ask your doctor for clinical guidance about its side effects.

What to do if I miss the dose?

Always try to be punctual in taking your medicine.  Although if you miss the dose for any reasons just skip it if it is almost time for your subsequent dose.

Refrain from taking two doses at a time.

Common Drug Interaction with Fedratinib.

Often it is unsafe to take particular medicines simultaneously as they may impact the blood absorption levels of a drug, increase side- effects, and even alter their efficacy.

Apprise your medical practitioner about all medicines you take, including prescription and over-the-counter drugs, vitamins, and herbal supplements.

Bottom Line

Fedratinib is recommended to treat myelofibrosis. This medicine should be used as per the guidance and instructions of your doctor. Any ignorance for the affected person may cause complications.

Talk to your doctor if you encounter any side- effects or ill- responses.

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